Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

25 Jan 2023

Abstract excerpt

The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus. Some reports have led to annotation of both Orf3a proteins as viroporins. Here, we show that neither SARS-CoV-2 nor SARS-CoV-1 Orf3a form functional ion conducting pores and that the conductances measured are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36695574
DOI: 10.7554/elife.84477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteinsPMID 36695574Read ↗

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteinsSemantic proximity Read ↗

Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern.Semantic proximity Read ↗

The Accessory Protein ORF3a Hijacks CLCC1 Chloride Channel to Cause ER Dysfunction in Beta-coronavirus PathogenesisSemantic proximity Read ↗

Unification and extensive diversification of M/Orf3-related ion channel proteins in coronaviruses and other nidovirusesSemantic proximity Read ↗

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 on Intracellular Trafficking, Autophagy, and ApoptosisSemantic proximity Read ↗

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particlesSemantic proximity Read ↗

The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and PathogenesisSemantic proximity Read ↗

Exhaustive mutational analysis of severe acute respiratory syndrome coronavirus 2 ORF3a: An essential component in the pathogen's infectivity cycle.Semantic proximity Read ↗

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell DeathSemantic proximity Read ↗

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral PathogenesisSemantic proximity Read ↗

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and PathogenesisSemantic proximity Read ↗

Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.