Article

The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes

2026-05-21

Abstract excerpt

<h4>Background</h4> The single nucleotide polymorphism (SNP) rs1053230 within the kynurenine 3-monooxygenase ( KMO ) gene encodes either an arginine ( C GC) or cysteine ( T GC) at amino acid residue 452. The rs1053230 genotype is associated with alterations in KMO expression and activity, and impaired cognition. Additionally, KMO intronic SNP rs2275163 is associated with schizophrenia endophenotypes. However,...

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Literature Corpus work: d46f839f-87f1-50b2-a976-751732e52ef4
DOI: 10.64898/2026.05.19.726163

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