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[Association of kynurenine-3-monooxygenase gene with schizophrenia].

Genetika - 1 Jun 2014

Golimbet V E, Lezheiko T V, Alfimova M V, Abramova L I, Kondrat'ev N V

Abstract excerpt

Neurotoxic products produced during tryptophan metabolism via the kynurenine pathway could be involved in schizophrenia pathogenesis. It has been shown that kynurenine-3-monooxygenase (KMO) is indirectly involved in these products' formation. KMO polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) were examined in 187 schizophrenia patients and 229 healthy subjects. A genetic combination of allele T and genotype...

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PMID: 25715464

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KMO

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