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Article

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.

Journal of psychiatry & neuroscience : JPN - 1 Jan 2012

Holtze Maria, Saetre Peter, Engberg Göran, Schwieler Lilly, Werge Thomas, Andreassen Ole A, Hall Håkan, Terenius Lars, Agartz Ingrid, Jönsson Erik G, Schalling Martin, Erhardt Sophie

Abstract excerpt

BACKGROUND: Patients with schizophrenia show increased brain and cerebrospinal fluid (CSF) concentrations of the endogenous N-methyl-D-aspartate receptor antagonist kynurenic acid (KYNA). This compound is an end-metabolite of the kynurenine pathway, and its formation indirectly depends on the activity of kynurenine 3-monooxygenase (KMO), the enzyme converting kynurenine to 3-hydroxykynurenine. METHODS: We...

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Identifiers

PMID: 21693093
DOI: 10.1503/jpn.100175
PMCID: PMC3244499

Genes

KMO

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Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.PMID 21693093Read ↗

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