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Article

The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.

Scientific reports - 2 Aug 2021

Bagheri Minoo, Wang Chuan, Shi Mingjian, Manouchehri Ali, Murray Katherine T, Murphy Matthew B, Shaffer Christian M, Singh Kritika, Davis Lea K, Jarvik Gail P, Stanaway Ian B, Hebbring Scott, Reilly Muredach P, Gerszten Robert E, Wang Thomas J, Mosley Jonathan D, Ferguson Jane F

Abstract excerpt

Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved in inflammation, associates with cardiometabolic disease risk. We used genetic approaches to identify inflammatory mechanisms associated with kynurenine...

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Identifiers

PMID: 34341450
DOI: 10.1038/s41598-021-95154-9
PMCID: PMC8329184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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