Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes.

Archives of general psychiatry - 1 Jul 2011

Wonodi Ikwunga, Stine O Colin, Sathyasaikumar Korrapati V, Roberts Rosalinda C, Mitchell Braxton D, Hong L Elliot, Kajii Yasushi, Thaker Gunvant K, Schwarcz Robert

Abstract excerpt

CONTEXT: Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan degradation, is an antagonist at N-methyl-d-aspartate and α7 nicotinic acetylcholine receptors and modulates glutamate, dopamine, and acetylcholine signaling. Cortical kynurenic acid concentrations are elevated in the brain and cerebrospinal fluid of schizophrenia patients. The proximal cause may be an impairment of kynurenine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Gene Expression Regulation, Enzymologic

Share to Genetic Association Studies

Share to Oculomotor Muscles

Share to RNA, Messenger

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 21727251
DOI: 10.1001/archgenpsychiatry.2011.71
PMCID: PMC3855543

Genes

KMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes.PMID 21727251Read ↗

Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia.Semantic proximity Read ↗

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.Semantic proximity Read ↗

The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypesSemantic proximity Read ↗

[Association of kynurenine-3-monooxygenase gene with schizophrenia].Semantic proximity Read ↗

Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatologySemantic proximity Read ↗

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.Semantic proximity Read ↗

Kynurenic acid promotes activity-dependent synaptic pruning in schizophreniaSemantic proximity Read ↗

Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.Semantic proximity Read ↗

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Semantic proximity Read ↗

Psychomotor slowing in Schizophrenia: Implications for endophenotype and biomarker developmentSemantic proximity Read ↗

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.Semantic proximity Read ↗

Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.