Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes.

Psychiatry research - 15 Aug 2011

Claes Stephan, Myint Aye-Mu, Domschke Katharina, Del-Favero Jurgen, Entrich Kathrin, Engelborghs Sebastiaan, De Deyn Peter, Mueller Norbert, Baune Bernhard, Rothermundt Matthias

Abstract excerpt

A consistent finding in major depressive disorder (MDD) research is dysfunction of the immune system. One of the relevant metabolic pathways in this regard is the kynurenine pathway. In patients with major depression, an imbalance between neuroprotective and neurotoxic arms of the pathway with lower plasma kynurenic acid concentration was demonstrated. Therefore, we investigated Single Nucleotide Polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Depressive Disorder, Major
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kynurenine

Share to Linkage Disequilibrium

Share to Psychiatric Status Rating Scales

Share to Signal Transduction

Share to Transaminases

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 21492941
DOI: 10.1016/j.psychres.2011.03.012

Genes

KMO
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes.PMID 21492941Read ↗

[A study of the association between the kynurenine-3-monooxygenase gene and depression].Semantic proximity Read ↗

Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.Semantic proximity Read ↗

The Genetic Landscape of Kynurenine Predicts Neurovascular Pathology and Disrupted White Matter Integrity in Patients With Mood Disorders.Semantic proximity Read ↗

The genetic landscape of kynurenine predicts neurovascular pathology and disrupted white matter integrity in patients with mood disordersSemantic proximity Read ↗

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity Read ↗

Genome-wide pathway analysis in major depressive disorder.Semantic proximity Read ↗

Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases.Semantic proximity Read ↗

Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophreniaSemantic proximity Read ↗

The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors; a systematic review and meta-analysisSemantic proximity Read ↗

Indoleamine 2,3-dioxygenase (IDO)-activity in Severe Psychiatric Disorders: A Systemic ReviewSemantic proximity Read ↗

Associations between Kynurenine pathway metabolites and cognitive dysfunction in major depressive disorderSemantic proximity Read ↗

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.