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Article

Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia.

Schizophrenia research - 1 Aug 2014

Wang Chenyao, Koide Takayoshi, Kimura Hiroki, Kunimoto Shohko, Yoshimi Akira, Nakamura Yukako, Kushima Itaru, Banno Masahiro, Kawano Naoko, Takasaki Yuto, Xing Jingrui, Noda Yukihiro, Mouri Akihiro, Aleksic Branko, Ikeda Masashi, Okada Takashi, Iidaka Tetsuya, Inada Toshiya, Iwata Nakao, Ozaki Norio

Abstract excerpt

The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candidate for mediating schizophrenia pathogenesis. Here, we investigated rare, deleterious single...

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Source

Identifiers

PMID: 24878430
DOI: 10.1016/j.schres.2014.04.032

Genes

FBXO45

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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