Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.

Schizophrenia research - 1 Sept 2009

Miller Christine L, Murakami Peter, Ruczinski Ingo, Ross Randal G, Sinkus Melissa, Sullivan Bernadette, Leonard Sherry

Abstract excerpt

Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Black or African American
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kynurenine

Share to Logistic Models

Share to Postmortem Changes

Share to Receptors, G-Protein-Coupled

Share to Receptors, Nicotinic

Source

Open in PubMed Open full text

Identifiers

PMID: 19502010
DOI: 10.1016/j.schres.2009.05.014
PMCID: PMC2855687

Genes

MCHR2
MCHR1
TDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19502010-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.PMID 19502010Read ↗

The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypesSemantic proximity Read ↗

Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.Semantic proximity Read ↗

A variant in the 3'-untranslated region of the MC2R gene decreases the risk of schizophrenia in a female Han Chinese population.Semantic proximity Read ↗

The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes.Semantic proximity Read ↗

[Association of kynurenine-3-monooxygenase gene with schizophrenia].Semantic proximity Read ↗

Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.Semantic proximity Read ↗

The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.Semantic proximity Read ↗

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.Semantic proximity Read ↗

Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.Semantic proximity Read ↗

Malic enzyme 2 and susceptibility to psychosis and mania.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.