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Article

Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.

Schizophrenia research - 1 Sept 2009

Miller Christine L, Murakami Peter, Ruczinski Ingo, Ross Randal G, Sinkus Melissa, Sullivan Bernadette, Leonard Sherry

Abstract excerpt

Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynurenine metabolites, to enhance risk for these psychiatric phenotypes. Candidate genes were selected...

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Source

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Identifiers

PMID: 19502010
DOI: 10.1016/j.schres.2009.05.014
PMCID: PMC2855687

Genes

MCHR2
MCHR1
TDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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