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Article

Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia.

Schizophrenia research - 1 Dec 2014

Wonodi Ikwunga, McMahon Robert P, Krishna Nithin, Mitchell Braxton D, Liu Judy, Glassman Matthew, Hong L Elliot, Gold James M

Abstract excerpt

BACKGROUND: Cognitive deficits compromise quality of life and productivity for individuals with schizophrenia and have no effective treatments. Preclinical data point to the kynurenine pathway of tryptophan metabolism as a potential target for pro-cognitive drug development. We have previously demonstrated association of a kynurenine 3-monooxygenase (KMO) gene variant with reduced KMO gene expression in...

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Identifiers

PMID: 25464917
DOI: 10.1016/j.schres.2014.10.026
PMCID: PMC4516229

Genes

KMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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