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Article

Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases.

Mutation research. Reviews in mutation research - 1 Jan 2000

Boros Fanni A, Bohár Zsuzsanna, Vécsei László

Abstract excerpt

Tryptophan is metabolized primarily via the kynurenine pathway (KP), which involves several enzymes, including indoleamine 2,3-dioxygenase, tryptophan 2,3 dioxygenase (TDO), kynurenine aminotransferases (KATs), kynurenine monooxygenase (KMO) etc. The majority of metabolites are neuroactive: some of them, such as kynurenic acid, show neuroprotective effects, while others contribute to free radical production,...

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Identifiers

PMID: 29807576
DOI: 10.1016/j.mrrev.2018.03.001

Genes

KMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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