Article

Heterogeneity of novel APOER2 isoforms specific to Alzheimer’s disease impact cellular and synaptic states

2023-01-13

Abstract excerpt

<h4>SUMMARY</h4> Apolipoprotein receptor 2 (APOER2) is an alternatively spliced transmembrane receptor that binds the neuroprotective ligand Reelin and Alzheimer’s disease (AD) related risk factor, APOE. Splicing of single exons in mouse Apoer2 regulates neuronal function and synaptic plasticity. However, the splicing landscape and function of human APOER2 isoforms in physiological and AD conditions remains uncl...

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Literature Corpus work: e14b11e5-9eaf-59a5-8284-df659cb977ab
DOI: 10.1101/2023.01.12.523804

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