Article

Sex-specific retina–brain signatures link ERα/ERβ imbalance with gliosis in Alzheimer’s disease

2026-05-05

Abstract excerpt

Women face a twofold higher lifetime risk of Alzheimer’s disease (AD) than men, yet the mechanisms underlying female-biased vulnerability and sex-specific disease signatures across the retina-brain axis remain unknown. By integrating clinicopathological and proteomic datasets from paired retinal and brain tissues from 182 donors, we identified sex-divergent molecular and pathological features across the AD continu...

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Literature Corpus work: 6c97cf91-1ba2-599b-a208-641e7241df5f
DOI: 10.64898/2026.04.30.722000

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