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The apolipoprotein receptor LRP3 compromises APP levels

2 Nov 2021

Abstract excerpt

BACKGROUND: Members of the low-density lipoprotein (LDL) receptor family are involved in endocytosis and in transducing signals, but also in amyloid precursor protein (APP) processing and β-amyloid secretion. ApoER2/LRP8 is a member of this family with key roles in synaptic plasticity in the adult brain. ApoER2 is cleaved after the binding of its ligand, the reelin protein, generating an intracellular domain...

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PMID: 34727970
DOI: 10.1186/s13195-021-00921-5

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