Article

Iron associated lipid peroxidation in Alzheimer’s disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

2023-03-29

Abstract excerpt

<h4> ABSTRACT </h4> Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer’s disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death. To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed postmortem human brain and ApoEFAD mice. AD brains had decreased antioxidant enzymes,...

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Literature Corpus work: b8d2bd29-c267-548d-bc70-7b6fe88aff2d
DOI: 10.1101/2023.03.28.534324

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Iron associated lipid peroxidation in Alzheimer’s disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in miceDOI 10.1101/2023.03.28.534324Read

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