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Article

CRAC channels and patho-physiology of peripheral organ systems.

Biochemical Society transactions - 30 Jun 2025

Bhardwaj Rajesh, Parekh Anant B

Abstract excerpt

A rise in cytosolic Ca2+ is used as a key signalling messenger in eukaryotic cells. The Ca2+ signal drives life and death and controls myriad responses in between. Inherent in the use of such a multifarious signal is the danger of disease, arising from dysregulated Ca2+ signalling. One ancient, highly conserved and widespread Ca2+ entry pathway is the store-operated Ca2+ release-activated Ca2+ (CRAC) channel....

Topics

Humans
Calcium Release Activated Calcium Channels
Animals
ORAI1 Protein
Stromal Interaction Molecule 1
Calcium Signaling
Calcium
Mutation
Neoplasm Proteins
Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 40459545
DOI: 10.1042/BST20253062
PMCID: PMC12224913

Genes

ORAI1
STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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