Article
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2010
McCarl Christie-Ann, Khalil Sara, Ma Jian, Oh-hora Masatsugu, Yamashita Megumi, Roether Jens, Kawasaki Takumi, Jairaman Amit, Sasaki Yoshiteru, Prakriya Murali, Feske Stefan
Abstract excerpt
ORAI1 is the pore-forming subunit of the Ca(2+) release-activated Ca(2+) (CRAC) channel, which is responsible for store-operated Ca(2+) entry in lymphocytes. A role for ORAI1 in T cell function in vivo has been inferred from in vitro studies of T cells from human immunodeficient patients with mutations in ORAI1 and Orai1(-/-) mice, but a detailed analysis of T cell-mediated immune responses in vivo in mice...
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