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Article

The many faces of Orai1 dysfunction: Molecular mechanisms and clinical manifestations.

The Journal of general physiology - 2 Nov 2026

Prantl Magdalena, Atzgerstorfer Lara, Radiskovic Tamara, Fahrner Marc, Derler Isabella

Abstract excerpt

Orai1, the pore-forming subunit of the calcium (Ca2+) release-activated Ca2+ (CRAC) channel, plays a central role in store-operated Ca2+ entry (SOCE) in animal cells and thereby serves as a key regulator of intracellular Ca2+ homeostasis. Disruption of this tightly controlled process is associated with a wide spectrum of human diseases. Dysfunction can result from a multitude of remodeling mechanisms, including...

Read the complete abstract on PubMed

Topics

Humans
ORAI1 Protein
Animals
Mutation
Calcium
Severe Combined Immunodeficiency
Miosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Malignant Hyperthermia

Ichthyosis

Myopathies, Structural, Congenital

Source

Identifiers

PMID: 42671323
DOI: 10.1085/jgp.202614031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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