Article

Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway

2022-11-29

Abstract excerpt

<h4>SUMMARY</h4> iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signalling; they function primarily by recognising transmembrane domains of their clients. Here we report an unexpected, and mechanistically distinct, nuclear function of iRhoms. iRhom2 is a non-canonical substrate of the signal peptidase complex (SPC), the protease tha...

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Literature Corpus work: bccfe027-9f8f-5c62-8ccf-c875fd13badb
DOI: 10.1101/2022.11.28.518246

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