Article
Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.
Molecular cell - 2 Dec 2021
Grieve Adam G, Yeh Yi-Chun, Chang Yu-Fen, Huang Hsin-Yi, Zarcone Lucrezia, Breuning Johannes, Johnson Nicholas, Stříšovský Kvido, Brown Marion H, Parekh Anant B, Freeman Matthew
Abstract excerpt
Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Through a bioinformatics-led cell biological screen, we have identified Orai1 as a substrate for the rhomboid intramembrane protease RHBDL2. We show that RHBDL2 prevents stochastic...
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