Article
The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations
23 Aug 2017
Abstract excerpt
The malaria parasite has co-evolved with its human host as each organism struggles for resources and survival. The scars of this war are carried in the human genome in the form of polymorphisms that confer innate resistance to malaria. Clinical, epidemiological and genome-wide association studies have identified multiple polymorphisms in red blood cell (RBC) proteins that attenuate malaria pathogenesis. These...
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