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Article

Single-genome sequencing reveals within-host evolution of human malaria parasites.

Cell host & microbe - 13 Oct 2021

Dia Aliou, Jett Catherine, Trevino Simon G, Chu Cindy S, Sriprawat Kanlaya, Anderson Timothy J C, Nosten François, Cheeseman Ian H

Abstract excerpt

Population genomics of bulk malaria infections is unable to examine intrahost evolution; therefore, most work has focused on the role of recombination in generating genetic variation. We used single-cell sequencing protocol for low-parasitaemia infections to generate 406 near-complete single Plasmodium vivax genomes from 11 patients sampled during sequential febrile episodes. Parasite genomes contain hundreds of...

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Identifiers

PMID: 34492224
DOI: 10.1016/j.chom.2021.08.009
PMCID: PMC8549078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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