Article

Quantitative analysis of signaling responses during mouse primordial germ cell specification

2021-01-12

Abstract excerpt

During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation. At the same time, a small population of pluripotent cells give rise to the primordial germ cells (PGCs), the precursors of the sperm and egg, which pass on heritable genetic information to the next generation. Despite the importance of PGC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d44745a3-20f0-5d7f-951d-1532ad92a9aa
DOI: 10.1101/2021.01.11.426293

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative analysis of signaling responses during mouse primordial germ cell specificationDOI 10.1101/2021.01.11.426293Read

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell developmentSemantic proximity Read

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.Semantic proximity Read

Of Mice and Men: In Vivo and In Vitro Studies of Primordial Germ Cell Specification.Semantic proximity Read

SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.Semantic proximity Read

Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissuesSemantic proximity Read

Mouse primordial germ cells lacking β1 integrins enter the germline but fail to migrate normally to the gonadsSemantic proximity Read

Smad5 is required for mouse primordial germ cell development.Semantic proximity Read

Requirement of Bmp8b for the generation of primordial germ cells in the mouse.Semantic proximity Read

BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovarySemantic proximity Read

Rapid estrogen signalling in mouse primordial germ cellsSemantic proximity Read

Epigenetic reprogramming in mouse primordial germ cells.Semantic proximity Read

Blimp1 is a critical determinant of the germ cell lineage in mice.Semantic proximity Read