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Article

Blimp1 is a critical determinant of the germ cell lineage in mice.

Nature - 14 Jul 2005

Ohinata Yasuhide, Payer Bernhard, O'Carroll Dónal, Ancelin Katia, Ono Yukiko, Sano Mitsue, Barton Sheila C, Obukhanych Tetyana, Nussenzweig Michel, Tarakhovsky Alexander, Saitou Mitinori, Surani M Azim

Abstract excerpt

Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from extraembryonic tissues. The specification of approximately 40 founder primordial germ cells and their segregation from somatic neighbours are important events in early development. We have proposed that a critical event during this specification includes repression of a somatic programme that is adopted by neighbouring...

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Identifiers

PMID: 15937476
DOI: 10.1038/nature03813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Blimp1 is a critical determinant of the germ cell lineage in mice.PMID 15937476Read ↗

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Epigenetic reprogramming in mouse primordial germ cells.Semantic proximity Read ↗

SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.Semantic proximity Read ↗

BMP signals and the transcriptional repressor BLIMP1 during germline segregation in the mammalian embryoSemantic proximity Read ↗

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.Semantic proximity Read ↗

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.Semantic proximity Read ↗

Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration.Semantic proximity Read ↗

BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovarySemantic proximity Read ↗

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.Semantic proximity Read ↗

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