Article
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.
Mechanisms of development - 1 Oct 2002
Hayashi Katsuhiko, Kobayashi Takashi, Umino Takashi, Goitsuka Ryo, Matsui Yasuhisa, Kitamura Daisuke
Abstract excerpt
Commitment of the germ cell lineage during embryogenesis depends on zygotic gene expression in mammals, but little is known about the signaling molecules required for germ cell formation. Here we show that the intracellular signaling molecule SMAD1, acting downstream of bone morphogenetic protein (BMP) receptors, is required for the commitment of germ cell lineage from epiblast in early mouse embryos. Smad1...
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