Article
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Genes & development - 15 Feb 1999
Lawson K A, Dunn N R, Roelen B A, Zeinstra L M, Davis A M, Wright C V, Korving J P, Hogan B L
Abstract excerpt
In many organisms the allocation of primordial germ cells (PGCs) is determined by the inheritance of maternal factors deposited in the egg. However, in mammals, inductive cell interactions are required around gastrulation to establish the germ line. Here, we show that Bmp4 homozygous null embryos contain no PGCs. They also lack an allantois, an extraembryonic mesodermal tissue derived, like the PGCs, from...
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