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Article

Mouse primordial germ cells lacking β1 integrins enter the germline but fail to migrate normally to the gonads

15 Apr 1999

Abstract excerpt

Primordial germ cells are the founder cells of the gametes. They are set aside at the initial stages of gastrulation in mammals, become embedded in the hind-gut endoderm, then actively migrate to the sites of gonad formation. The molecular basis of this migration is poorly understood. Here we sought to determine if members of the integrin family of cell surface receptors are required for primordial germ cell...

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PMID: 10079228
DOI: 10.1242/dev.126.8.1655

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