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Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues

1 Aug 2023

Abstract excerpt

Primordial germ cells (PGCs) are the early embryonic precursors of gametes - sperm and egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells exposed to signalling cocktails and aggregated into large embryonic bodies, but these do not recapitulate the native embryonic environment during PGC formation. Here, we show that mouse gastruloids, a three-dimensional in vitro model of...

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PMID: 37526602
DOI: 10.1242/dev.201790

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