Article
Requirement of Bmp8b for the generation of primordial germ cells in the mouse.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2000
Ying Y, Liu X M, Marble A, Lawson K A, Zhao G Q
Abstract excerpt
In the mouse embryo, the generation of primordial germ cells (PGCs) from the epiblast requires a bone morphogenetic protein-4 (BMP4) signal from the adjacent extraembryonic ectoderm. In this study, we report that Bmp8b, a member of the Gbb-60A class of the BMP superfamily, is expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos and is required for PGC generation. A mutation in...
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