Article

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development

2018-11-07

Abstract excerpt

The essential roles played by Nodal and Bmp signalling during early mouse development have been extensively documented. Here we used conditional deletion strategies to investigate functional contributions made by Nodal, Bmp and Smad downstream effectors during primordial germ cell (PGC) development. We demonstrate that Nodal and its target gene Eomes provide early instructions during formation of the PGC lineage....

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Literature Corpus work: 90cc31e9-329f-583c-bdf3-dc0165902437
DOI: 10.1101/464776

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