Article

IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need to be fully elucidated. Rather than focusing on specific inflammatory stimuli, we here investigat...

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Literature Corpus work: d445b316-1a9d-54d3-b4c6-16b1dd8a3503
DOI: 10.1101/2023.01.24.525321

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