Article

IRF8 restrains a neutrophil alarmin program that drives inflammatory remodeling of the bone marrow niche

2026-06-25

Abstract excerpt

<title>Abstract</title> <p>Tissue inflammation is shaped by reciprocal interactions between immune cells and stromal niches, yet how leukemic myelopoiesis rewires these circuits remains poorly understood. Here, we identify suppression of interferon regulatory factor 8 (IRF8) in hematopoietic cells as a driver of inflammatory bone marrow niche remodeling in chronic-phase myeloid leukemia (CP-CML). IRF8 expression...

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Literature Corpus work: 5cf54101-1a31-57c7-8118-d40adc0b7c1a
DOI: 10.21203/rs.3.rs-9942483/v1

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