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The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease

23 Jul 2018

Abstract excerpt

PURPOSE OF REVIEW: Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that participates in the regulation of hematopoietic stem cells (HSC) during development and under homeostatic conditions. IFN-γ also plays a key pathogenic role in several diseases that affect hematopoiesis including aplastic anemia, hemophagocytic lymphohistiocytosis, and cirrhosis of the liver. RECENT FINDINGS: Studies have shown that...

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PMID: 30148048
DOI: 10.1007/s40778-018-0139-3

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