Article

Inflammatory Recruitment of Healthy Hematopoietic Stem and Progenitor Cells in the Acute Myeloid Leukemia Niche

2023-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation in the bone marrow (BM) microenvironment is a constitutive component of leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both leukemic blasts and stroma secrete proinflammatory factors that actively suppress the function of healthy hematopoietic stem and progenitor cells (HSPCs). HSPCs are also cellular components of the innate immune system, and we rea...

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Literature Corpus work: 30cd4325-c86e-5ec2-b240-324d4af31c78
DOI: 10.1101/2023.11.22.566265

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