Article

Analysis of novel domain-specific mutations in the zebrafish <i>ndr2/cyclops</i> gene generated using CRISPR-Cas9 RNPs

2018-03-06

Abstract excerpt

Nodal-related protein (ndr2) is a member of the transforming growth factor type β superfamily of factors and is required for ventral midline patterning of the embryonic central nervous system in zebrafish. In humans, mutations in the gene encoding nodal cause holoprosencephaly and heterotaxy. Mutations in the ndr2 gene in the zebrafish ( Danio rerio ) lead to similar phenotypes, including loss of the medial floo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d442a718-120d-5bd1-b0f1-51d41f97a6cd
DOI: 10.1101/277715

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of novel domain-specific mutations in the zebrafish <i>ndr2/cyclops</i> gene generated using CRISPR-Cas9 RNPsDOI 10.1101/277715Read

cyclops encodes a nodal-related factor involved in midline signaling.Semantic proximity Read

Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases.Semantic proximity Read

Efficient CRISPR genome editing and integrative genomic analyses reveal the mosaicism of Cas-induced mutations and pleiotropic effects of <i>scarlet</i> gene in an emerging model systemSemantic proximity Read

Proof of concept study deploying CRISPR inhibition and activation opens new avenues for systematic biological exploration in zebrafishSemantic proximity Read

Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes.Semantic proximity Read

Dkk1 inhibition normalizes limb phenotypes in a mouse model of <i>Fzd2</i> associated omodysplasia Robinow syndromesSemantic proximity Read

Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos.Semantic proximity Read

Conditional knockouts generated by engineered CRISPR-Cas9 endonuclease reveal the roles of coronin in C. elegans neural development.Semantic proximity Read

Genome Editing in <i>Caenorhabditis briggsae</i> using the CRISPR/Cas9 SystemSemantic proximity Read

CRISPR/Cas9-mediated grna gene knockout leads to neurodevelopmental defects and motor behavior changes in zebrafish.Semantic proximity Read

Multiple genome modifications by the CRISPR/Cas9 system in zebrafish.Semantic proximity Read

Detection of Multiple Genome Modifications Induced by the CRISPR/Cas9 System.Semantic proximity Read