Article

Proof of concept study deploying CRISPR inhibition and activation opens new avenues for systematic biological exploration in zebrafish

2024-09-19

Abstract excerpt

<h4>ABSTRACT</h4> The application of CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) technologies in zebrafish has the potential to expand its capacity for the study of gene function significantly. We report proof-of-principle data evaluating transient expression of a codon optimized CRISPRi/a system for zebrafish across established pigmentary and growth phenotypes. A codon-optimized and catalytical...

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Literature Corpus work: afc18d6b-7cd2-5bf3-857d-1a17f95cacb6
DOI: 10.1101/2024.09.16.613289

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