Article
cyclops encodes a nodal-related factor involved in midline signaling.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Rebagliati M R, Toyama R, Haffter P, Dawid I B
Abstract excerpt
Ventral structures in the central nervous system are patterned by signals emanating from the underlying mesoderm as well as originating within the neuroectoderm. Mutations in the zebrafish, Danio rerio, are proving instrumental in dissecting these midline signals. The cyclops mutation leads to a loss of medial floor plate and to severe deficits in ventral forebrain development, leading to cyclopia. Here, we...
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