Article
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes.
DNA repair - 1 Nov 2021
Shin Unbeom, Nakhro Khriezhanuo, Oh Chang-Kyu, Carrington Blake, Song HeaIn, Varshney Gaurav K, Kim Yeongjae, Song Hyemin, Jeon Sangeun, Robbins Gabrielle, Kim Sangin, Yoon Suhyeon, Choi Yong Jun, Kim Yoo Jung, Burgess Shawn, Kang Sukhyun, Sood Raman, Lee Yoonsung, Myung Kyungjae
Abstract excerpt
A systematic knowledge of the roles of DNA repair genes at the level of the organism has been limited due to the lack of appropriate experimental approaches using animal model systems. Zebrafish has become a powerful vertebrate genetic model system with availability due to the ease of genome editing and large-scale phenotype screening. Here, we generated zebrafish mutants for 32 DNA repair and replication genes...
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