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Article

CRISPR/Cas9-mediated grna gene knockout leads to neurodevelopmental defects and motor behavior changes in zebrafish.

Journal of neurochemistry - 1 May 2021

Zhu Jiuling, Xu Huimin, Song Hui, Li Xiang, Wang Ning, Zhao Junli, Zheng Xiaojing, Kim Kwang-Youn, Zhang Hui, Mao Qinwen, Xia Haibin

Abstract excerpt

Progranulin (PGRN) is a secreted glycoprotein with multiple biological functions in early embryogenesis, anti-inflammation, and neurodegeneration. A good model for the functional study of PGRN is the zebrafish with knockdown or knockout of grn, the gene encoding PGRN. Morpholino oligonucleotides (MOs) and zinc finger nucleases have been used to generate zebrafish grn models, yet they have shown inconsistent...

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PMID: 33480022
DOI: 10.1111/jnc.15307

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