Article

CNSistent integration and feature extraction from somatic copy number profiles

2024-12-23

Abstract excerpt

The vast majority of cancers exhibit Somatic Copy Number Alterations (SCNAs)—gains and losses of variable regions of DNA. SCNAs can shape the phenotype of cancer cells, e . g . by increasing their proliferation rates, removing tumor suppressor genes, or immortalizing cells. While many SCNAs are unique to a patient, certain recurring patterns emerge as a result of shared selectional constraints or common mutation...

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Literature Corpus work: d43cf084-549f-514d-96e5-459d12f218e3
DOI: 10.1101/2024.12.23.630118

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