Article

CESAR: A R Package for High-Sensitivity Detection of Copy Number Variations in ctDNA Using Segmentation and Anchor Recalibration

2026-03-11

Abstract excerpt

<h4>Background</h4> Detecting copy number variations (CNVs) in circulating tumor DNA (ctDNA) is crucial for the companion diagnosis and resistance monitoring of various solid tumors (e.g., NSCLC, Glioblastoma). However, when tumor-derived DNA fractions are extremely low (often <1%), traditional depth-based methods frequently fail due to non-linear sequencing depth fluctuations and probe-specific capture biases in...

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Literature Corpus work: 1ff25773-320f-5bcf-80d8-4ebf3a517339
DOI: 10.64898/2026.03.09.710442

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