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Article

Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.

Biomolecules - 4 Nov 2022

Sitzia Giacomo, Skiteva Olga, Chergui Karima

Abstract excerpt

Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are frequent causes of familial Parkinson's Disease (PD), an increasingly prevalent neurodegenerative disease that affects basal ganglia circuitry. The cellular effects of the G2019S mutation in the LRRK2 gene, the most common pathological mutation, have not been thoroughly investigated. In this study we used middle-aged mice carrying the...

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Identifiers

PMID: 36358985
DOI: 10.3390/biom12111635
PMCID: PMC9687271

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Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.PMID 36358985Read ↗

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