Article

Location of NMDARs and co-agonist control the generation of bursts in nigral dopamine neurons

2024-06-06

Abstract excerpt

NMDA receptor activation in pars compacta substantia nigra dopamine neurons is central to the generation of bursting activity, a key signal temporally associated to movement initiation. The site of the NMDAR pool (synaptic and/or extrasynaptic) as well as the identity of the co-agonist involved in the ignition of this phasic activity remains unknown. Using ex vivo electrophysiological recordings, we demonstrate t...

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Literature Corpus work: afe5ce29-701f-51c4-9720-b91540550d10
DOI: 10.1101/2024.06.06.597701

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