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Article

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.

Neurobiology of aging - 1 Dec 2003

Li Lijun, Fan Mannie, Icton Carolyn D, Chen Nansheng, Leavitt Blair R, Hayden Michael R, Murphy Tim H, Raymond Lynn A

Abstract excerpt

N-Methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity has been proposed to play a role in Huntington disease (HD), caused by expansion of a polyglutamine tract in the protein huntingtin. HD is characterized by selective neurodegeneration most severely affecting striatal medium-sized spiny projection neurons (MSNs), where expression of the NMDAR subunit NR2B is increased relative to other NR2 subunits....

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PMID: 14643383
DOI: 10.1016/j.neurobiolaging.2003.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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