Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.

doi:10.1016/j.neurobiolaging.2003.04.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.

Neurobiology of aging - 1 Dec 2003

Li Lijun, Fan Mannie, Icton Carolyn D, Chen Nansheng, Leavitt Blair R, Hayden Michael R, Murphy Tim H, Raymond Lynn A

Abstract excerpt

N-Methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity has been proposed to play a role in Huntington disease (HD), caused by expansion of a polyglutamine tract in the protein huntingtin. HD is characterized by selective neurodegeneration most severely affecting striatal medium-sized spiny projection neurons (MSNs), where expression of the NMDAR subunit NR2B is increased relative to other NR2 subunits....

Topics

Animals
Cells, Cultured
Disease Models, Animal
Genetic Predisposition to Disease
Huntingtin Protein
Huntington Disease
Membrane Potentials
Mice
Mice, Transgenic
Mutation
Neostriatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Degeneration

Nerve Tissue Proteins

Neurons

Nuclear Proteins

Receptors, AMPA

Receptors, N-Methyl-D-Aspartate

Synaptic Transmission

Source

Open in PubMed

Identifiers

PMID: 14643383
DOI: 10.1016/j.neurobiolaging.2003.04.003

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.PMID 14643383Read ↗

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.Semantic proximity Read ↗

Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s DiseaseSemantic proximity Read ↗

Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's DiseaseSemantic proximity Read ↗

Mutant huntingtin enhances excitotoxic cell death.Semantic proximity Read ↗

NMDA receptor function in mouse models of Huntington disease.Semantic proximity Read ↗

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.Semantic proximity Read ↗

BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.Semantic proximity Read ↗

Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer’s DiseaseSemantic proximity Read ↗

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.Semantic proximity Read ↗

N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.Semantic proximity Read ↗

Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative DiseasesSemantic proximity Read ↗

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.