Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2.

PloS one - 1 Jan 2012

Perreault Melissa L, Fan Theresa, Alijaniaram Mohammed, O'Dowd Brian F, George Susan R

Abstract excerpt

In basal ganglia a significant subset of GABAergic medium spiny neurons (MSNs) coexpress D1 and D2 receptors (D1R and D2R) along with the neuropeptides dynorphin (DYN) and enkephalin (ENK). These coexpressing neurons have been recently shown to have a region-specific distribution throughout the mesolimbic and basal ganglia circuits. While the functional relevance of these MSNs remains relatively unexplored, they...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basal Ganglia
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescence

Share to gamma-Aminobutyric Acid

Share to Glutamate Decarboxylase

Share to Multiprotein Complexes

Share to Receptors, Dopamine D1

Share to Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 22428025
DOI: 10.1371/journal.pone.0033348
PMCID: PMC3299775

Genes

BDNF
MSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2.PMID 22428025Read ↗

Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.Semantic proximity Read ↗

Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compactaSemantic proximity Read ↗

Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson’s DiseaseSemantic proximity Read ↗

Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.Semantic proximity Read ↗

Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system.Semantic proximity Read ↗

Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype.Semantic proximity Read ↗

Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compactaSemantic proximity Read ↗

Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum.Semantic proximity Read ↗

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors.Semantic proximity Read ↗

D2 autoreceptors gate vulnerability to cocaine use disorderSemantic proximity Read ↗

Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum.Semantic proximity Read ↗

Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.