Article

Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s Disease

2016-09-23

Abstract excerpt

<h4>BACKGROUND</h4> Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disease causing severe neurodegeneration of the striatum as well as marked cognitive and motor disabilities. Excitotoxicity, caused by overstimulation of NMDA receptors (NMDARs) has been shown to have a key role in the neuropathogenesis of HD, suggesting that targeting NMDAR-dependent signaling may be an effective clinical ap...

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Literature Corpus work: 5d9d11b0-a9f6-594e-8420-6d5c4eb6d3ee
DOI: 10.1101/076885

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