Article

Empirical estimation of multiple-testing burden for population-based HLA association studies using sequencing-derived HLA alleles across genetic ancestries

2026-07-15

Abstract excerpt

As population-scale whole-genome sequencing datasets continue to expand, they enable genetic association studies beyond single-nucleotide variants to more complex forms of genetic variation, including classical human leukocyte antigen (HLA) alleles. The HLA region comprises nine highly polymorphic classical HLA genes in extensive linkage disequilibrium that are associated with numerous autoimmune and infectious di...

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Literature Corpus work: d4141602-c2c5-511d-8cdc-92818b663598
DOI: 10.64898/2026.07.12.738059

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