Article
In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales.
Briefings in bioinformatics - 20 May 2021
Chen Jieming, Madireddi Shravan, Nagarkar Deepti, Migdal Maciej, Vander Heiden Jason, Chang Diana, Mukhyala Kiran, Selvaraj Suresh, Kadel Edward E, Brauer Matthew J, Mariathasan Sanjeev, Hunkapiller Julie, Jhunjhunwala Suchit, Albert Matthew L, Hammer Christian
Abstract excerpt
Immunogenetic variation in humans is important in research, clinical diagnosis and increasingly a target for therapeutic intervention. Two highly polymorphic loci play critical roles, namely the human leukocyte antigen (HLA) system, which is the human version of the major histocompatibility complex (MHC), and the Killer-cell immunoglobulin-like receptors (KIR) that are relevant for responses of natural killer...
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