Article

Optimal HLA imputation of admixed population with dimension reduction

2023-04-13

Abstract excerpt

Human genomics has quickly evolved, powering genome-wide association studies (GWASs). SNP-based GWASs cannot capture the intense polymorphism of HLA genes, highly associated with disease susceptibility. There are methods to statistically impute HLA genotypes from SNP-genotypes data, but lack of diversity in reference panels hinders their performance. We evaluated the accuracy of the 1,000 Genomes data as a refer...

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Literature Corpus work: 7676fce2-bd43-5a0d-b245-772ee6e9cb3d
DOI: 10.1101/2023.04.12.536582

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