Article

ROP16-mediated activation of STAT6 facilitates encystment of type III <i>Toxoplasma gondii</i> in neurons

2022-07-31

Abstract excerpt

Toxoplasma gondii establishes a long-lived latent infection in the central nervous system (CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life threatening disease. Latent infection is driven by the ability of the parasite to convert from the acute-stage tachyzoite to the latent-stage bradyzoite which resides in long-lived intracellular cysts. While much work has focused on the parasit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d40ff6a3-b844-5e32-8f35-036e29446533
DOI: 10.1101/2022.07.31.502204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ROP16-mediated activation of STAT6 facilitates encystment of type III <i>Toxoplasma gondii</i> in neuronsDOI 10.1101/2022.07.31.502204Read

Secreted protein kinases regulate cyst burden during chronic toxoplasmosisSemantic proximity Read

The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responsesSemantic proximity Read

Translocation of dense granule effectors across the parasitophorous vacuole membrane in <i>Toxoplasma</i> -infected cells requires the activity of ROP17, a rhoptry protein kinaseSemantic proximity Read

TgROP18 Targets IL20RB for Host-Defense-Related-STAT3 Activation During T. gondii InfectionSemantic proximity Read

Toxoplasma gondii rhoptry protein38 (TgROP38) affects parasite invasion, egress, and induces IL-18 secretion during early infection.Semantic proximity Read

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma- Infected Cells Requires the Activity of ROP17, a Rhoptry Protein KinaseSemantic proximity Read

<i>Toxoplasma gondii</i> PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector exportSemantic proximity Read

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulenceSemantic proximity Read

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.Semantic proximity Read

ATF6β is a host cellular target of the <i>Toxoplasma gondii</i> virulence factor ROP18Semantic proximity Read

The<i>Toxoplasma gondii</i>rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7Semantic proximity Read

Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restrictionSemantic proximity Read